AZD3839
Catalog No: 17022710
CAS Number: 1227163-56-5
Purity: 98%
AZD3839 is a potent and selective BACE1 inhibitor. AZD3839 is clinical candidate for the treatment of Alzheimer disease. AZD3839 inhibits BACE1 activity, A and sAPP release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons. Selectivity against BACE2 and cathepsin D was 14 and >1000-fold, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid A levels in mouse, guinea pig, and non-human primate. AZD3839 effectively reduces the levels of A in brain, CSF, and plasma in several preclinical species.
For research use only. We do not sell to patients.
Chemical Information
| Name | AZD3839 |
|---|---|
| Iupac Chemical Name | (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine |
| Synonyms | N/A |
| Molecular Formula | C24H16F3N5 |
| Molecular Weight | 431.4222 |
| Smile | FC(C1=NC=CC(=C1)[C@@]1(N=C(C2=C(C=CC=C12)F)N)C1=CC(=CC=C1)C=1C=NC=NC1)F |
| InChiKey | MRXBCEQZNKUUIP-DEOSSOPVSA-N |
| InChi | InChI=1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1 |
| CAS Number | 1227163-56-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
