Abrocitinib
Catalog No: 19381
CAS Number: 1622902-68-4
Purity: >98%
Abrocitinib, Bulk in stock, contact us by email for the quotation. Kg scale intermediates are also be provided by custom synthesis.
Abrocitinib is an oral small molecule that selectively inhibits Janus kinase (JAK) 1. Inhibition of JAK1 is thought to modulate multiple cytokines involved in pathophysiology of atopic dermatitis, including interleukin (IL)-4, IL-13, IL-31, IL-22, and thymic stromal lymphopoietin (TSLP).
For research use only. We do not sell to patients.
Chemical Information
| Name | Abrocitinib |
|---|---|
| Iupac Chemical Name | N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide |
| Synonyms | PF-04965842; PF 04965842; PF04965842; Abrocitinib; |
| Molecular Formula | C14H21N5O2S |
| Molecular Weight | 323.41 |
| Smile | CCCS(=O)(N[C@H]1C[C@@H](N(C)C2=C3C(NC=C3)=NC=N2)C1)=O |
| InChiKey | IUEWXNHSKRWHDY-PHIMTYICSA-N |
| InChi | InChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)/t10-,11+ |
| CAS Number | 1622902-68-4 |
| Related CAS | 2204280-33-9 (trans-isomer) 1622902-68-4 (cis-isomer) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | >98% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Vazquez ML, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152.
Chemical Structure
