Alentemol HBr
Alentemol, also known as U-66444B and alentamol, is a selective dopamine autoreceptor agonist described as an antipsychotic. Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin.
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Chemical Information
| Name | Alentemol HBr |
|---|---|
| Iupac Chemical Name | 2-(dipropylamino)-2,3-dihydro-1H-phenalen-5-ol hydrobromide |
| Synonyms | Alentemol HBr; Alentemol hydrobromide; Alentemol, alentamol, U-66444B; U 66444B; U66444B; |
| Molecular Formula | C19H26BrNO |
| Molecular Weight | 364.32 |
| Smile | OC1=CC2=C3C(CC(N(CCC)CCC)C2)=CC=CC3=C1.[H]Br |
| InChiKey | FWRWEZVGVJKNMU-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H25NO.BrH/c1-3-8-20(9-4-2)17-10-14-6-5-7-15-12-18(21)13-16(11-17)19(14)15;/h5-7,12-13,17,21H,3-4,8-11H2,1-2H3;1H |
| CAS Number | 112892-51-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
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| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
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| Clinical study |
1: Yu RL, Aaron CS, Ulrich RG, Thilagar A, Kumaroo PV, Wang Y. Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin. Environ Mol Mutagen. 1992;20(3):172-87. doi: 10.1002/em.2850200306. PMID: 1396608.
2: Althaus JS, Decker DE, Von Voigtlander PF, Buxser SE. Effects of dopamine agonists on dopamine secretion from PC12 cells: lack of functional autoreceptor activity. Res Commun Chem Pathol Pharmacol. 1991 May;72(2):131-42. PMID: 1678897.
3: Schwende FJ, Rykert UM. Determination of alentamol hydrobromide, a novel antipsychotic agent, in human blood plasma and urine by high-performance liquid chromatography with fluorescence detection and solid-phase extraction. J Chromatogr. 1991 Apr 19;565(1-2):488-96. doi: 10.1016/0378-4347(91)80415-9. PMID: 1874898.
4: Piercey MF, Broderick PA, Hoffmann WE, Vogelsang GD. U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. PMID: 1974631.
Chemical Structure
