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BAY-1816032

Catalog No: 2071615
CAS Number: 1891087-61-8
Purity: 98% Min.

BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. BAY 1816032 showed long target residence time and induced chromosome mis-segregation upon combination with low concentrations of paclitaxel. It was synergistic or additive in combination with paclitaxel or docetaxel, as well as with ATR or PARP inhibitors in cellular assays. Tumor xenograft studies demonstrated a strong and statistically significant reduction of tumor size and excellent tolerability upon combination of BAY 1816032 with paclitaxel or olaparib as compared with the respective monotherapies.


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Chemical Information

NameBAY-1816032
Iupac Chemical Name2-(3,5-difluoro-4-((3-(5-methoxy-4-((3-methoxypyridin-4-yl)amino)pyrimidin-2-yl)-1H-indazol-1-yl)methyl)phenoxy)ethan-1-ol
SynonymsBAY-1816032; BAY 1816032; BAY1816032
Molecular Formula C27H24F2N6O4
Molecular Weight534.5238
SmileCOC1=C(NC2=NC(C3=NN(CC4=C(F)C=C(OCCO)C=C4F)C5=C3C=CC=C5)=NC=C2OC)C=CN=C1
InChiKeyQVOGVAVHOLLLAZ-UHFFFAOYSA-N
InChiInChI=1S/C27H24F2N6O4/c1-37-23-13-30-8-7-21(23)32-26-24(38-2)14-31-27(33-26)25-17-5-3-4-6-22(17)35(34-25)15-18-19(28)11-16(12-20(18)29)39-10-9-36/h3-8,11-14,36H,9-10,15H2,1-2H3,(H,30,31,32,33)
CAS Number1891087-61-8
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Ordering Information

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Formulation固体粉末
Purity98% Min.
Storage短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
Solubility可溶于DMSO
Handling
Shipping Condition作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

Siemeister G, Mengel A, Fernández-Montalván AE, et al. Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo. Clin Cancer Res. 2019;25(4):1404–1414. doi:10.1158/1078-0432.CCR-18-0628

Chemical Structure

2071615 - BAY-1816032 | CAS 1891087-61-8

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