BAY1217389
Catalog No: 16060801
CAS Number: 1554458-53-5
Purity: 98% by HPLC
BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells
For research use only. We do not sell to patients.
Chemical Information
| Name | BAY1217389 |
|---|---|
| Iupac Chemical Name | N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide |
| Synonyms | BAY1217389; BAY-1217389 |
| Molecular Formula | C27H24F5N5O3 |
| Molecular Weight | 561.513 |
| Smile | C1(CC1)NC(C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2NCCC(F)(F)F)OC2=C(C(=C(C=C2)OC)F)F)C)=O |
| InChiKey | WNEILUNVMHVMPH-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38) |
| CAS Number | 1554458-53-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
