BIX02188
Catalog No: 122205
CAS Number: 334949-59-6
Purity: 98%
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
For research use only. We do not sell to patients.
Chemical Information
| Name | BIX02188 |
|---|---|
| Iupac Chemical Name | (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide |
| Synonyms | BIX 02188; BIX-02188 |
| Molecular Formula | C25H24N4O2 |
| Molecular Weight | 412.48 |
| Smile | O=C(C3=CC(NC2=O)=C(C=C3)/C2=C(NC4=CC=CC(CN(C)C)=C4)\C1=CC=CC=C1)N |
| InChiKey | FSZPIAXLCCQFCM-FCQUAONHSA-N |
| InChi | InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22- |
| CAS Number | 334949-59-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
