BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM, which was reported to inhibit catalytic function of purified, MEK5 enzyme.
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Chemical Information
Name | BIX 02189 |
Iupac Chemical Name | (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide |
Synonyms | BIX02189; BIX-02189 |
Molecular Formula | C27H28N4O2 |
Molecular Weight | 440.53682 |
Smile | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=CC(CN(C)C)=C3)/C4=CC=CC=C4)N(C)C |
InChiKey | HOMJAAIVTDVQJA-IZHYLOQSSA-N |
InChi | InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24- |
CAS Number | 1265916-41-3 |
Related CAS | |
Ordering Information
Packaging | Price | Availability | Purity | Shipping Time |
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Formulation | Solid powder |
Purity | 98% |
Storage | -20 ºC for 3 years |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |