BMS-3
Catalog No: 16071026
CAS Number: 1338247-30-5
Purity: 98% by HPLC
BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 M BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
For research use only. We do not sell to patients.
Chemical Information
| Name | BMS-3 |
|---|---|
| Iupac Chemical Name | N-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide |
| Synonyms | BMS-3; BMS 3 |
| Molecular Formula | C17H12Cl2F2N4OS |
| Molecular Weight | 429.2668 |
| Smile | ClC1=C(C(=CC=C1)Cl)N1N=C(C=C1C1=CN=C(S1)NC(=O)C1CC1)C(F)F |
| InChiKey | YBGGBHCJSAEIAS-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26) |
| CAS Number | 1338247-30-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
