Bardoxolone methyl
Catalog No: 92303
CAS Number: 218600-53-4
Purity: 98%
Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Bardoxolone methyl is currently being developed by Reata Pharmaceuticals, Inc. in partnership with Abbott Laboratories and Kyowa Hakko Kirin, for the treatment of advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients.
For research use only. We do not sell to patients.
Chemical Information
| Name | Bardoxolone methyl |
|---|---|
| Iupac Chemical Name | (4aS,6aR,6bS,12aS,14aR,14bR)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate |
| Synonyms | CDDO Methyl ester; CDDO-Me; NSC 713200; RTA 402; RTA402; RTA-402 |
| Molecular Formula | C32H43NO4 |
| Molecular Weight | 505.69 |
| Smile | C(#N)C=1C(C(C2CC[C@]3([C@@]4(CC[C@]5(CCC(C[C@@H]5[C@H]4C(C=C3[C@]2(C1)C)=O)(C)C)C(=O)OC)C)C)(C)C)=O |
| InChiKey | WPTTVJLTNAWYAO-OROHISIGSA-N |
| InChi | InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22?,24+,29+,30-,31-,32+/m1/s1 |
| CAS Number | 218600-53-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
