Basimglurant, also known as RO 4917523 and RG-7090, is a novel mGlu5 negative allosteric modulator currently in Phase 2 clinical development for MDD and Fragile X syndrome (FXS).
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Chemical Information
Name Basimglurant
Iupac Chemical Name 2-chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl)ethynyl)pyridine
Synonyms RG-7090; RG 7090; RG7090; RO4917523; RO 4917523; RO-4917523; Basimglurant
Molecular Formula C18H13ClFN3
Molecular Weight 325.77
Smile CC1=C(C#CC2=CC(Cl)=NC=C2)N=C(C)N1C3=CC=C(F)C=C3
InChiKey UPZWINBEAHDTLA-UHFFFAOYSA-N
InChi InChI=1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7,9-11H,1-2H3
CAS Number 1034442-21-1
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation Off-white solid to white solid
Purity >98%
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study