Briciclib
Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.
Briciclib inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM). Cyclin D1 is a protein required for normal progression through the cell cycle and is overexpressed in many tumors. Cyclin D1 expression is regulated through a process termed cap-dependent translation, which requires the function of eukaryotic initiation factor 4E (eIF4E) protein. In vitro evidence indicates that briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death. Briciclib is potent and shown to be active in nonclinical tumor models when combined with several chemotherapeutics.
For research use only. We do not sell to patients.
Chemical Information
| Name | Briciclib |
|---|---|
| Iupac Chemical Name | Briciclib |
| Synonyms | ON-014185; ON014185; ON 014185 |
| Molecular Formula | C19H23O10PS |
| Molecular Weight | 474.42 |
| Smile | COc1ccc(cc1OP(=O)(O)O)CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC |
| InChiKey | LXENKEWVEVKKGV-BQYQJAHWSA-N |
| InChi | InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+ |
| CAS Number | 865783-99-9 |
| MDL | MFCD22665751 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Chemical Structure
