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CBiPES HCl

Catalog No: 20558
CAS Number: 856702-40-4
Purity: 98% Min.

CBiPES HCl is a selective positive allosteric modulator of the mGlu2 receptor.

For research use only. We do not sell to patients.

Chemical Information

NameCBiPES HCl
Iupac Chemical Name N-(4'-cyano-[1,1'-biphenyl]-3-yl)-N-(pyridin-3-ylmethyl)ethanesulfonamide hydrochloride
SynonymsCBiPES hydrochloride; 856702-40-4; DL3XSQ69E9; CBiPES (hydrochloride); UNII-DL3XSQ69E9
Molecular FormulaC21H20ClN3O2S
Molecular Weight413.92
SmileO=S(N(CC2=CC=CN=C2)C1=CC(C3=CC=C(C#N)C=C3)=CC=C1)(CC)=O.Cl
InChiKeyQKUHSVQWWZBAKM-UHFFFAOYSA-N
InChiInChI=1S/C21H19N3O2S.ClH/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19;/h3-13,15H,2,16H2,1H3;1H
CAS Number856702-40-4
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Frouni I, Kwan C, Nuara SG, Belliveau S, Kang W, Hamadjida A, Bédard D,
Gourdon JC, Huot P. Effect of the mGlu2 positive allosteric modulator
CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-
lesioned marmoset. J Neural Transm (Vienna). 2021 Jan;128(1):73-81. doi:
10.1007/s00702-020-02287-8. Epub 2021 Jan 3. PMID: 33392826.

2: Benvenga MJ, Chaney SF, Baez M, Britton TC, Hornback WJ, Monn JA, Marek GJ.
Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head
Twitches Induced by a Serotonergic Hallucinogen in Mice. Front Pharmacol. 2018
Mar 15;9:208. doi: 10.3389/fphar.2018.00208. PMID: 29599719; PMCID: PMC5862811.

3: Caulder EH, Riegle MA, Godwin DW. Activation of group 2 metabotropic
glutamate receptors reduces behavioral and electrographic correlates of
pilocarpine induced status epilepticus. Epilepsy Res. 2014 Feb;108(2):171-81.
doi: 10.1016/j.eplepsyres.2013.10.009. Epub 2013 Nov 16. PMID: 24305700; PMCID:
PMC4378620.

4: Johnson PL, Fitz SD, Engleman EA, Svensson KA, Schkeryantz JM, Shekhar A.
Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent
sodium lactate-induced panic-like response in panic-vulnerable rats. J
Psychopharmacol. 2013 Feb;27(2):152-61. doi: 10.1177/0269881112454230. Epub 2012
Aug 21. PMID: 22914798; PMCID: PMC4300988.

5: Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, McKinzie
DL, Nisenbaum ES, Tizzano JP, Schoepp DD. Metabotropic glutamate 2 receptor
potentiators: receptor modulation, frequency-dependent synaptic activity, and
efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology
(Berl). 2005 Apr;179(1):271-83. doi: 10.1007/s00213-004-2099-9. Epub 2005 Feb
17. PMID: 15717213.

Chemical Structure

20558 - CBiPES HCl | CAS 856702-40-4

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