CC-90009 is a modulator of cereblon (CRBN), which is part of the cullin 4-RING E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase; CUL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and pro-apoptotic activities.
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Name | CC-90009 |
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Iupac Chemical Name | 2-(4-Chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
Synonyms | CC-90009 ; CC 90009 ; CC90009 |
Molecular Formula | C22H18ClF2N3O4 |
Molecular Weight | 461.85 |
Smile | ClC1=CC=C(C=C1)C(C(=O)NCC=1C=C2CN(C(C2=CC1)=O)C1C(NC(CC1)=O)=O)(F)F |
InChiKey | PWBHUSLMHZLGRN-UHFFFAOYSA-N |
InChi | InChI=1S/C22H18ClF2N3O4/c23-15-4-2-14(3-5-15)22(24,25)21(32)26-10-12-1-6-16-13(9-12)11-28(20(16)31)17-7-8-18(29)27-19(17)30/h1-6,9,17H,7-8,10-11H2,(H,26,32)(H,27,29,30) |
CAS Number | 1860875-51-9 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | Off-white solid to white solid |
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Purity | 98% |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Solubility | Soluble in DMSO, not in water |
Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
Shipping Condition | Shipped under ambient temperature |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |