CH5132799 (PA-799)
Catalog No: 160926015
CAS Number: 1007207-67-1
Purity: 98% by HPLC
CH5132799, also known as PA-799, is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3K (IC(50)=0.014 M). In human tumor cell lines with PI3K pathway activation, CH5132799 showed potent antiproliferative activity. CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice. CH5132799 selectively inhibited class I PI3Ks and PI3K mutants in in vitro kinase assays. Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.
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Chemical Information
| Name | CH5132799 (PA-799) |
|---|---|
| Iupac Chemical Name | 5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine |
| Synonyms | CH5132799; CH-5132799; CH 5132799; PA-799; PA799; PA-799. |
| Molecular Formula | C15H19N7O3S |
| Molecular Weight | 377.42146 |
| Smile | CS(=O)(=O)N1CCC2=C1N=C(N=C2C=2C=NC(=NC2)N)N2CCOCC2 |
| InChiKey | JEGHXKRHKHPBJD-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H19N7O3S/c1-26(23,24)22-3-2-11-12(10-8-17-14(16)18-9-10)19-15(20-13(11)22)21-4-6-25-7-5-21/h8-9H,2-7H2,1H3,(H2,16,17,18) |
| CAS Number | 1007207-67-1 |
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Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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