CP-673451 is a selective inhibitor of PDGFR/ with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, and has anti-angiogenic and anti-tumor activity.
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Chemical Information
Name CP-673451
Iupac Chemical Name 1-(2-(5-(2-Methoxyethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-ylamine
Synonyms CP-673,451; CP-673451;
Molecular Formula C24H27N5O2
Molecular Weight 417.5
Smile COCCOC1=CC2=C(N(C=N2)C2=NC3=C(C=CC=C3C=C2)N2CCC(CC2)N)C=C1
InChiKey DEEOXSOLTLIWMG-UHFFFAOYSA-N
InChi InChI=1S/C24H27N5O2/c1-30-13-14-31-19-6-7-21-20(15-19)26-16-29(21)23-8-5-17-3-2-4-22(24(17)27-23)28-11-9-18(25)10-12-28/h2-8,15-16,18H,9-14,25H2,1H3
CAS Number 343787-29-1
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation Solid powder
Purity 98% by HPLC
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study