Compound 401
Catalog No: 611816
CAS Number: 168425-64-7
Purity: 98%
Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 M) that also targets mTOR but not PI3K.
Compound 401 shows activity against mTOR (IC50 = 5.3 M) but not p110/p85 PI3K (IC50 > 100 M). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).
For research use only. We do not sell to patients.
Chemical Information
| Name | Compound 401 |
|---|---|
| Iupac Chemical Name | Compound 401 |
| Synonyms | Compound-401; Compound401 |
| Molecular Formula | C16H15N3O2 |
| Molecular Weight | 281.31 |
| Smile | c1ccc2c(c1)ccn3c2nc(cc3=O)N4CCOCC4 |
| InChiKey | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2 |
| CAS Number | 168425-64-7 |
| MDL | MFCD10568147 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
