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Compound E

Catalog No: 20575
CAS Number: 209986-17-4
Purity: 98% Min.

Compound E is a cell-permeable, potent, selective inhibitor of ɣ-secretase and Notch processing.

For research use only. We do not sell to patients.

Chemical Information

NameCompound E
Iupac Chemical Name(S,S)-2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide
SynonymsCompound E; GSI-XXI; ɣ-secretase inhibitor XXI; GSI XXI; GSIXXI;
Molecular FormulaC27H24F2N4O3
Molecular Weight490.50
SmileC[C@H](NC(CC1=CC(F)=CC(F)=C1)=O)C(N[C@H]2N=C(C3=CC=CC=C3)C4=CC=CC=C4N(C)C2=O)=O
InChiKeyJNGZXGGOCLZBFB-IVCQMTBJSA-N
InChiInChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
CAS Number209986-17-4
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Formulation固体粉末
Purity98% Min.
Storage短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
Solubility溶于DMSO
Handling
Shipping Condition作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Burns CM. The History of Cortisone Discovery and Development. Rheum Dis Clin North Am. 2016 Feb;42(1):1-14, vii. doi: 10.1016/j.rdc.2015.08.001. Review. PubMed PMID: 26611547.

2: Zhai X, Chen F, Zhu C, Lu Y. A simple LC-MS/MS method for the determination of cortisol, cortisone and tetrahydro-metabolites in human urine: assay development, validation and application in depression patients. J Pharm Biomed Anal. 2015 Mar 25;107:450-5. doi: 10.1016/j.jpba.2015.01.041. Epub 2015 Jan 25. PubMed PMID: 25668797.

3: Saenger AK. Discovery of the wonder drug: from cows to cortisone. The effects of the adrenal cortical hormone 17-hydroxy-11-dehydrocorticosterone (Compound E) on the acute phase of rheumatic fever; preliminary report. Mayo Clin Proc 1949;24:277-97. Clin Chem. 2010 Aug;56(8):1349-50. doi: 10.1373/clinchem.2010.149120. Epub 2010 Jun 10. PubMed PMID: 20538878.

4: Buer JK. [NSAID - when the most important thing was not to be cortisone]. Tidsskr Nor Laegeforen. 2016 May 24;136(9):842. doi: 10.4045/tidsskr.16.0141. eCollection 2016 May. Norwegian. PubMed PMID: 27221187.

5: Luo X, Zheng L, Cai N, Liu Q, Yang S, He X, Cheng Z. Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism. J Pharm Sci. 2015 Oct;104(10):3578-86. doi: 10.1002/jps.24566. Epub 2015 Jul 6. PubMed PMID: 26150050.

6: Nally E. Itching for a solution: how topical steroids became a standard treatment for eczema. Pharm Hist (Lond). 2014 Sep;44(3):56-64. PubMed PMID: 25335225.

7: KENDALL EC. Some observations on the hormone of the adrenal cortex designated compound E. Proc Staff Meet Mayo Clin. 1949 May 25;24(11):298-301. PubMed PMID: 18130002.

8: I recently received a cortisone injection in my knee, and it substantially reduced the pain and stiffness. How often can I safely have these injections? Will there be side effects? Mayo Clin Health Lett. 2014 May;32(5):8. PubMed PMID: 25046880.

9: Zheng L, Luo X, Zhu L, Xie W, Liu S, Cheng Z. Simultaneous determination of cortisol, cortisone, 6β-hydroxycortisol and 6β-hydroxycortisone by HPLC. J Chromatogr Sci. 2015 Apr;53(4):451-5. doi: 10.1093/chromsci/bmt034. Epub 2015 Jan 26. PubMed PMID: 25628347.

10: Albano N, Santiago-Quesada F, Masero JA, Sánchez-Guzmán JM, Möstl E. Immunoreactive cortisone in droppings reflect stress levels, diet and growth rate of gull-billed tern chicks. Gen Comp Endocrinol. 2015 Mar 1;213:74-80. doi: 10.1016/j.ygcen.2015.02.019. Epub 2015 Mar 2. PubMed PMID: 25743158.

11: de la Torre X, Curcio D, Colamonici C, Molaioni F, Cilia M, Botrè F. Development and validation of a GC-C-IRMS method for the confirmation analysis of pseudo-endogenous glucocorticoids in doping control. Drug Test Anal. 2015 Nov-Dec;7(11-12):1071-8. doi: 10.1002/dta.1911. Epub 2015 Nov 25. PubMed PMID: 26607312.

12: HENCH PS, SLOCUMB CH, et al. The effects of the adrenal cortical hormone 17-hydroxy-11-dehydrocorticosterone (Compound E) on the acute phase of rheumatic fever; preliminary report. Proc Staff Meet Mayo Clin. 1949 May 25;24(11):277-97. PubMed PMID: 18130001.

13: Jadreškić D. Some social aspects of discovery, synthesis and production of cortisone in the 1930s-1950s. Acta Med Hist Adriat. 2016 Dec;14(2):333-346. PubMed PMID: 28038491.

14: Kido T, Dao TV, Ho MD, Duc Dang N, Pham NT, Okamoto R, Pham TT, Maruzeni S, Nishijo M, Nakagawa H, Honma S, Le SK, Nguyen HN. High cortisol and cortisone levels are associated with breast milk dioxin concentrations in Vietnamese women. Eur J Endocrinol. 2013 Nov 29;170(1):131-9. doi: 10.1530/EJE-13-0410. Print 2014 Jan. PubMed PMID: 24123093.

15: van der Voorn B, de Waard M, van Goudoever JB, Rotteveel J, Heijboer AC, Finken MJ. Breast-Milk Cortisol and Cortisone Concentrations Follow the Diurnal Rhythm of Maternal Hypothalamus-Pituitary-Adrenal Axis Activity. J Nutr. 2016 Nov;146(11):2174-2179. Epub 2016 Sep 14. PubMed PMID: 27629575.

16: Antonelli G, Artusi C, Marinova M, Brugnolo L, Zaninotto M, Scaroni C, Gatti R, Mantero F, Plebani M. Cortisol and cortisone ratio in urine: LC-MS/MS method validation and preliminary clinical application. Clin Chem Lab Med. 2014 Feb;52(2):213-20. doi: 10.1515/cclm-2013-0471. PubMed PMID: 24391193.

17: Chen Z, Li J, Xu G, Yang J, Zhang J, Deng H. Simultaneous measurements of cortisol and cortisone in urine and hair for the assessment of 11β-hydroxysteroid dehydrogenase activity among methadone maintenance treatment patients with LC-ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:77-84. doi: 10.1016/j.jchromb.2014.08.001. Epub 2014 Aug 10. PubMed PMID: 25151333.

18: Shen Y, Wang F, Wang Y, Zhao Q, Wang M. Cyclic utilization of HP-β-CD in the bioconversion of cortisone acetate by Arthrobacter simplex. Biotechnol Lett. 2016 Apr;38(4):597-602. doi: 10.1007/s10529-015-2022-y. Epub 2015 Dec 24. PubMed PMID: 26704767.

19: Hellgren C, Edvinsson Å, Olivier JD, Fornes R, Stener-Victorin E, Ubhayasekera SJ, Skalkidou A, Bergquist J, Sundström-Poromaa I. Tandem mass spectrometry determined maternal cortisone to cortisol ratio and psychiatric morbidity during pregnancy-interaction with birth weight. Psychoneuroendocrinology. 2016 Jul;69:142-9. doi: 10.1016/j.psyneuen.2016.04.006. Epub 2016 Apr 7. PubMed PMID: 27088373.

20: Zheng N, Christopher LJ, Ma X, Ji QC, Buzescu A, Kandoussi H, Garonzik SM, LaCreta F, Aubry AF, Arnold ME, Zeng J. UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions. Bioanalysis. 2016 Dec;8(23):2429-2443. PubMed PMID: 27855510.

Chemical Structure

20575 - Compound E | CAS 209986-17-4

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