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Compound E

Catalog No: 20575
CAS Number: 209986-17-4
Purity: 98% Min.

Compound E is a cell-permeable, potent, selective inhibitor of ɣ-secretase and Notch processing.

For research use only. We do not sell to patients.

Chemical Information

NameCompound E
Iupac Chemical Name(S,S)-2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide
SynonymsCompound E; GSI-XXI; ɣ-secretase inhibitor XXI; GSI XXI; GSIXXI;
Molecular FormulaC27H24F2N4O3
Molecular Weight490.50
SmileC[C@H](NC(CC1=CC(F)=CC(F)=C1)=O)C(N[C@H]2N=C(C3=CC=CC=C3)C4=CC=CC=C4N(C)C2=O)=O
InChiKeyJNGZXGGOCLZBFB-IVCQMTBJSA-N
InChiInChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
CAS Number209986-17-4
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Ordering Information

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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

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Chemical Structure

20575 - Compound E | CAS 209986-17-4

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