DHPG, also known as (RS)-3,5-DHPG, is a selective agonist for group I metabotropic glutamate receptors (mGluRs), specifically targeting mGluR1 and mGluR5. Activation of these receptors by 3,5-DHPG has been shown to influence synaptic transmission and neuronal excitability. 3,5-DHPG, through its action on group I mGluRs, can modulate synaptic activity by promoting spontaneous neurotransmitter release in a patterned manner, which may have implications for understanding synaptic dynamics and developing therapeutic strategies targeting these receptors.
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Name | DHPG |
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Iupac Chemical Name | 2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
Synonyms | DHPG; (RS)-3,5-DHPG |
Molecular Formula | C8H9NO4 |
Molecular Weight | 183.16 |
Smile | O=C(O)C(N)C1=CC(O)=CC(O)=C1 |
InChiKey | HOOWCUZPEFNHDT-UHFFFAOYSA-N |
InChi | InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13) |
CAS Number | 146255-66-5 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | Off-white solid |
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Purity | 98% Min. |
Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |