Daprodustat (Synonyms: GSK1278863)
Daprodustat (Synonyms: GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
Daprodustat (GSK1278863), Bulk in stock, contact us by email for Bulk quotation. Kg scale intermediates are also be provided by custom synthesis.
For research use only. We do not sell to patients.
Chemical Information
| Name | Daprodustat (Synonyms: GSK1278863) |
|---|---|
| Iupac Chemical Name | (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine |
| Synonyms | GSK1278863; GSK 1278863; GSK-1278863; Daprodustat |
| Molecular Formula | C19H27N3O6 |
| Molecular Weight | 393.43 |
| Smile | C1(CCCCC1)N1C(N(C(C(C1=O)C(=O)NCC(=O)O)=O)C1CCCCC1)=O |
| InChiKey | RUEYEZADQJCKGV-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24) |
| CAS Number | 960539-70-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Brigandi RA, et al. A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial. Am J Kidney Dis. 2016 Jun;67(6):861-71
[2]. Hara K, et al. Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8
Chemical Structure
