Eptapirone, also known as F11440, is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone.
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Chemical Information
Name
Eptapirone
Iupac Chemical Name
Eptapirone
Synonyms
F11440; F-11440; F 11440; Eptapirone; L0068; L-0068; L 0068