FIIN-3
Catalog No: 16122945
CAS Number: 1637735-84-2
Purity: 98%
FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R. (Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.)
For research use only. We do not sell to patients.
Chemical Information
| Name | FIIN-3 |
|---|---|
| Iupac Chemical Name | FIIN-3 |
| Synonyms | FIIN3; FIIN 3 |
| Molecular Formula | C34H36Cl2N8O4 |
| Molecular Weight | 691.60684 |
| InChiKey | |
| InChi | |
| CAS Number | 1637735-84-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
