Fezolinetant
Fezolinetant, also known as ESN-364, is Neurokinin-3 (NK-3) receptor antagonist which has been optimized for use in women’s health, and is being developed for sex-hormone related disorders such as endometriosis, polycystic ovarian syndrome and uterine fibroids.
For research use only. We do not sell to patients.
Chemical Information
| Name | Fezolinetant |
|---|---|
| Iupac Chemical Name | (R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone |
| Synonyms | Fezolinetant ; ESN-364 ; ESN 364 ; ESN364 |
| Molecular Formula | C16H15FN6OS |
| Molecular Weight | 358.3954 |
| Smile | O=C(C1=CC=C(F)C=C1)N2[C@H](C)C3=NN=C(C4=NC(C)=NS4)N3CC2 |
| InChiKey | PPSNFPASKFYPMN-SECBINFHSA-N |
| InChi | InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1 |
| CAS Number | 1629229-37-3 |
| Related CAS | 1629229-37-3 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | >98% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
| Targets | Neurokinin-3 (NK-3) receptor antagonist |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Fraser GL, Ramael S, Hoveyda HR, Gheyle L, Combalbert J. The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26. doi: 10.1210/jc.2015-3621. Epub 2015 Dec 14. PubMed PMID: 26653113.
2: Fraser GL, Hoveyda HR, Clarke IJ, Ramaswamy S, Plant TM, Rose C, Millar RP. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25. doi: 10.1210/en.2015-1409. Epub 2015 Aug 25. PubMed PMID: 26305889.
Chemical Structure
