Foretinib(GSK1363089)
Catalog No: 51705
CAS Number: 849217-64-7
Purity: 98%
Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFR/ and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
For research use only. We do not sell to patients.
Chemical Information
| Name | Foretinib(GSK1363089) |
|---|---|
| Iupac Chemical Name | N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| Synonyms | Foretinib,GSK1363089,XL880 |
| Molecular Formula | C34H34F2N4O6 |
| Molecular Weight | 632.65 |
| Smile | FC=1C=C(C=CC1OC1=CC=NC2=CC(=C(C=C12)OC)OCCCN1CCOCC1)N(C(=O)C1(CC1)C(=O)N)C1=CC=C(C=C1)F |
| InChiKey | FCGJXAOTZFGHNQ-UHFFFAOYSA-N |
| InChi | InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-39-14-17-44-18-15-39)38-12-9-28(25)46-29-8-7-24(19-26(29)36)40(23-5-3-22(35)4-6-23)33(42)34(10-11-34)32(37)41/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H2,37,41) |
| CAS Number | 849217-64-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | 5mg/ml in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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