GDC-0214
iJak-381 is a highly potent, selective, and inhalable Janus kinase-1 (JAK-1) inhibitor which shows about 950 times higher concentration in the lungs than in plasma after inhalation in mice. iJak-381 suppresses the signal transducer and activator of transcription 6 activation by IL-13.
For research use only. We do not sell to patients.
Chemical Information
| Name | GDC-0214 |
|---|---|
| Iupac Chemical Name | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2-cyanoethyl)methylamino]-1-piperidinyl]-2-oxoethyl]-1H-pyrazol-4-yl]- |
| Synonyms | GDC-0214，iJak-381 |
| Molecular Formula | C28H28ClF2N9O3 |
| Molecular Weight | 612.03 |
| Smile | O=C(C4=C3N=CC=CN3N=C4)NC1=CN(CC(N5CCC(N(CCC#N)C)CC5)=O)N=C1C2=CC(Cl)=CC=C2OC(F)F |
| InChiKey | ITNFPSJJBYFVEA-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H28ClF2N9O3/c1-37(10-2-8-32)19-6-12-38(13-7-19)24(41)17-39-16-22(35-27(42)21-15-34-40-11-3-9-33-26(21)40)25(36-39)20-14-18(29)4-5-23(20)43-28(30)31/h3-5,9,11,14-16,19,28H,2,6-7,10,12-13,17H2,1H3,(H,35,42) |
| CAS Number | 1831144-46-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Dengler HS, Wu X, Peng I, Rinderknecht CH, Kwon Y, Suto E, Kohli PB, Liimatta M, Barrett K, Lloyd J, Cain G, Briggs M, Addo S, Salmon G, Ubhayakar S, Deshmukh G, Shahidi-Latham SK, Quiason-Huynh CM, Jackman J, Liu J, Ray NC, Goodacre SC, Johnson A, McKenzie BS, Lee WP, Zak M, Kenny JR, Ghilardi N. Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma. Sci Transl Med. 2018 Nov 21;10(468). pii: eaao2151. doi: 10.1126/scitranslmed.aao2151. PubMed PMID: 30463918.
Chemical Structure
