GSK2292767 is a potent and selective PI3K inhibitor.GSK2292767 is highly selective for PI3K over the closely related isoforms and is active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation
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Name | GSK2292767 |
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Iupac Chemical Name | N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide |
Synonyms | GSK2292767; GSK-2292767; GSK 2292767. |
Molecular Formula | C24H28N6O5S |
Molecular Weight | 512.58 |
Smile | C[C@H]1O[C@H](CN(C1)CC1=CN=C(O1)C1=C2C=NNC2=CC(=C1)C=1C=C(C(=NC1)OC)NS(=O)(=O)C)C |
InChiKey | NLUPPCTVKHDVIQ-GASCZTMLSA-N |
InChi | InChI=1S/C24H28N6O5S/c1-14-11-30(12-15(2)34-14)13-18-9-26-23(35-18)19-5-16(6-21-20(19)10-27-28-21)17-7-22(29-36(4,31)32)24(33-3)25-8-17/h5-10,14-15,29H,11-13H2,1-4H3,(H,27,28)/t14-,15+ |
CAS Number | 1254036-66-2 |
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Formulation | crystalline solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
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Clinical study |