GSK872 is a a receptor interacting protein kinase-3 (RIP3) inhibitor. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced by toll-like receptor 3 (TLR3).
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Name | GSK872 |
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Synonyms | GSK872; GSK-872; GSK 872; |
Molecular Formula | C19H17N3O2S2 |
Molecular Weight | 383.484 |
Smile | O=S(C1=CC=C2N=CC=C(NC3=CC=C(SC=N4)C4=C3)C2=C1)(C(C)C)=O |
InChiKey | ZCDBTQNFAPKACC-UHFFFAOYSA-N |
InChi | InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22) |
CAS Number | 1346546-69-7 |
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Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | off-white solid |
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Purity | >98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO, not in water |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |