Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; IC50 for GM1 inhibition is 14 nM
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Name | Genz-123346 |
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Iupac Chemical Name | N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)nonanamide |
Synonyms | Genz-123346;Genz123346;Genz 123346 |
Molecular Formula | C24H38N2O4 |
Molecular Weight | 418.57 |
Smile | O1C2=C(OCC1)C=C(C=C2)[C@H]([C@@H](CN2CCCC2)NC(CCCCCCCC)=O)O |
InChiKey | JMNXWOFCUJJYEO-HYBUGGRVSA-N |
InChi | InChI=1S/C24H38N2O4/c1-2-3-4-5-6-7-10-23(27)25-20(18-26-13-8-9-14-26)24(28)19-11-12-21-22(17-19)30-16-15-29-21/h11-12,17,20,24,28H,2-10,13-16,18H2,1H3,(H,25,27)/t20-,24-/m1/s1 |
CAS Number | 491833-30-8 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Formulation | off-white solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | 50mg/ml in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature. |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |