Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
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Chemical Information
Name Givinostat HCl
Iupac Chemical Name (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride
Synonyms ITF2357; ITF-2357; ITF 2357; ITF2357 HCl; ITF2357 hydrochloride; Givinostat HCl. gavinostat.
Molecular Formula C24H28ClN3O4
Molecular Weight 457.955
Smile Cl.ONC(=O)C1=CC=C(C=C1)NC(OCC1=CC2=CC=C(C=C2C=C1)CN(CC)CC)=O
InChiKey QKSGNWJOQMSBEP-UHFFFAOYSA-N
InChi InChI=1S/C24H27N3O4.ClH/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H
CAS Number 199657-29-9
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation off-white solid
Purity 98.0%
Storage -20 ℃ for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study