HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.
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Name | HS-1371 |
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Iupac Chemical Name | 7-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline |
Synonyms | HS-1371; HS 1371; HS1371; |
Molecular Formula | C24H24N4O |
Molecular Weight | 384.48 |
Smile | CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1 |
InChiKey | VPVLPCIBKVWFDT-UHFFFAOYSA-N |
InChi | InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3 |
CAS Number | 2158197-70-5 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | Off-white solid to white solid |
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Purity | >98% |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Solubility | Soluble in DMSO, not in water |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |