M40403 is a low molecular weight, synthetic manganese containing superoxide dismutase mimetic (SODm) that removes superoxide anions (*O2-) without interfering with other reactive species known to be involved in inflammatory responses (e.g. nitric oxide, NO and peroxynitrite, ONOO-). As such, M40403 represents an important pharmacological tool to dissect the roles of *O2- in acute and chronic inflammation.
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Name | Imisopasem-manganese(M40403) |
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Iupac Chemical Name | (4R,9R,14R,19R)-3,10,13,20,26-Pentaazatetracyclo[20.3.1.0~4,9~.0~14,19~]hexacosa-1(26),22,24-triene-dichloromanganese |
Synonyms | M-40403;M 40403;CG4419;CG 4419;CG-4419;SC-72325;SC72325;SC 72325 |
Molecular Formula | C21H35Cl2MnN5 |
Molecular Weight | 483.38 |
Smile | Cl[Mn]Cl.C1=2CN[C@@H]3CCCC[C@H]3NCCN[C@@H]3CCCC[C@H]3NCC(=CC=C1)N2 |
InChiKey | WXEMWBBXVXHEPU-XNPJUPKFSA-L |
InChi | InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1 |
CAS Number | 218791-21-0 |
Related CAS |
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Formulation | off-white solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder 6 months-80ºCin solvent |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
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Cell study | |
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Clinical study |