JH-VIII-157-02, a structural analogue of alectinib, is potent against the G1202R mutant as well as a variety of other frequently observed mutants. In addition, it is capable of penetrating the CNS of mice following oral dosing.
For research use only. We do not sell to patients.
Chemical Information
Name JH-VIII-157-02
Iupac Chemical Name 1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-
Synonyms JH-VIII-157-02;CAS#1639422-97-1
Molecular Formula C28H27N5O2
Molecular Weight 465.55
Smile O=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1
InChiKey IDGNCVHQDDOPND-UHFFFAOYSA-N
InChi InChI=1S/C28H27N5O2/c1-6-17-10-21-22(11-20(17)18-13-30-33(14-18)15-24(34)32(4)5)28(2,3)27-25(26(21)35)19-8-7-16(12-29)9-23(19)31-27/h7-11,13-14,31H,6,15H2,1-5H3
CAS Number 1639422-97-1
Related CAS
Ordering Information
Packaging Price Availability Purity Shipping Time
Bulk Enquiry Enquiry Enquiry
Formulation Solid powder
Purity 98% by HPLC
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study