KDM5-C49
KDM5-C49 is a potent and selective inhibitor of KDM5 (also known as JARID1). KDM5-C49 displays 25-100-fold selectivity between KDM5B and KDM6B. Members of the KDM5 (also known as JARID1) family regulate cell proliferation and stem cell self-renewal and differentiation.
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Chemical Information
| Name | KDM5-C49 |
|---|---|
| Iupac Chemical Name | 2-{[(2-{[2-(Dimethylamino)ethyl](ethyl)amino}-2-oxoethyl)amino]methyl}isonicotinic Acid |
| Synonyms | KDM5-C49; KDM5 C49; KDM5C49; |
| Molecular Formula | C15H24N4O3 |
| Molecular Weight | 308.38 |
| Smile | O=C(O)C1=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C1 |
| InChiKey | RGGMVQDDHDCRDM-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22) |
| CAS Number | 1596348-16-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess-Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. doi: 10.1038/nchembio.2087. Epub 2016 May 23. PubMed PMID: 27214403.
Chemical Structure
