KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 M in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
For research use only. We do not sell to patients.
Name | KS176 |
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Iupac Chemical Name | N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide |
Synonyms | KS 176; KS-176 |
Molecular Formula | C22H19N3O5 |
Molecular Weight | 405.4 |
Smile | OCCC1=CC=C(C=C1)NC(C1=C(C=CC=C1)NC(C1=CC=C(C=C1)[N+](=O)[O-])=O)=O |
InChiKey | LTWQQWSXYYXVGA-UHFFFAOYSA-N |
InChi | InChI=1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27) |
CAS Number | 1253452-78-6 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | crystalline solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |