KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50 / Ki of 12.9 nM/2.2 nM, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
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Chemical Information
Name KU-55933
Iupac Chemical Name 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
Synonyms N/A
Molecular Formula C21H17NO3S2
Molecular Weight 395.49
Smile O1CCN(CC1)C=1OC(=CC(C1)=O)C1=CC=CC=2SC3=CC=CC=C3SC12
InChiKey XRKYMMUGXMWDAO-UHFFFAOYSA-N
InChi InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
CAS Number 587871-26-9
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Ordering Information
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Formulation crystalline solid
Purity 98%
Storage 3 years -20ºCpowder 6 months-80ºCin solvent
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study