KU 57788
Catalog No: 160926003
CAS Number: 503468-95-9
Purity: 98% by HPLC
Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin andetoposidein vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.
For research use only. We do not sell to patients.
Chemical Information
| Name | KU 57788 |
|---|---|
| Iupac Chemical Name | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| Synonyms | NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. |
| Molecular Formula | C25H19NO3S |
| Molecular Weight | 413.49 |
| Smile | C1=CC=C(C=2SC3=C(C21)C=CC=C3)C3=CC=CC=2C(C=C(OC23)N2CCOCC2)=O |
| InChiKey | JAMULYFATHSZJM-UHFFFAOYSA-N |
| InChi | InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2 |
| CAS Number | 503468-95-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
