L755507
Catalog No: 16122732
CAS Number: 159182-43-1
Purity: 98%
L-755,507 is characterized as a potent and selective 3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.L-755,507 displays an excellent activity profile as an extremely potent human 3 adrenergic receptor agonist (3 EC50 0.43 nM), with >440-fold selectivity over 1 and 2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human 3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold.
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Chemical Information
| Name | L755507 |
|---|---|
| Iupac Chemical Name | L755507 |
| Synonyms | N/A |
| Molecular Formula | C30H40N4O6S |
| Molecular Weight | 584.73 |
| Smile | CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)CCNC[C@@H](COc3ccc(cc3)O)O |
| InChiKey | NYYJKMXNVNFOFQ-MHZLTWQESA-N |
| InChi | InChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1 |
| CAS Number | 159182-43-1 |
| MDL | MFCD08703099 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
