LRRK2-IN-1
Catalog No: 81001
CAS Number: 1234480-84-2
Purity: 97%
LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. IC50 is 13 nM, 6 nM, and 2.45 M for wild type, G2019S mutant, and drug resistant A2016T mutant LRRK2, respectively.
For research use only. We do not sell to patients.
Chemical Information
| Name | LRRK2-IN-1 |
|---|---|
| Iupac Chemical Name | 2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Synonyms | LRRK 2-IN-1 |
| Molecular Formula | C31H38N8O3 |
| Molecular Weight | 570.69 |
| Smile | COC1=C(NC=2N=CC3=C(N(C4=C(C(N3C)=O)C=CC=C4)C)N2)C=CC(=C1)C(=O)N1CCC(CC1)N1CCN(CC1)C |
| InChiKey | IWMCPJZTADUIFX-UHFFFAOYSA-N |
| InChi | InChI=1S/C31H38N8O3/c1-35-15-17-38(18-16-35)22-11-13-39(14-12-22)29(40)21-9-10-24(27(19-21)42-4)33-31-32-20-26-28(34-31)36(2)25-8-6-5-7-23(25)30(41)37(26)3/h5-10,19-20,22H,11-18H2,1-4H3,(H,32,33,34) |
| CAS Number | 1234480-84-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 97% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
