LY2109761
Catalog No: 16123039
CAS Number: 700874-71-1
Purity: 98%
LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases.
For research use only. We do not sell to patients.
Chemical Information
| Name | LY2109761 |
|---|---|
| Iupac Chemical Name | LY2109761 |
| Synonyms | LY 2109761; LY-2109761 |
| Molecular Formula | C26H27N5O2 |
| Molecular Weight | 441.52 |
| Smile | c1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6 |
| InChiKey | IHLVSLOZUHKNMQ-UHFFFAOYSA-N |
| InChi | InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2 |
| CAS Number | 700874-71-1 |
| MDL | MFCD12923354 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
