LY2334737
Catalog No: 16123040
CAS Number: 892128-60-8
Purity: 98%
LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity. LY2334737 is hydrolyzed by carboxylesterase 2 (CES2) and releases gemcitabine systemically over a period of time consistent with formation rate-limited kinetics. In turn, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate and triphosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP is incorporated into DNA, resulting in premature termination of DNA replication and eventually the induction of apoptosis. Compared to gemcitabine, this prodrug is able to avoid hydrolysis in enterocytes and the portal circulation thus avoiding first pass metabolism and increasing systemic gemcitabine availability.
For research use only. We do not sell to patients.
Chemical Information
| Name | LY2334737 |
|---|---|
| Iupac Chemical Name | LY2334737 |
| Synonyms | LY 2334737; LY-2334737; gemcitabine prodrug |
| Molecular Formula | C17H25F2N3O5 |
| Molecular Weight | 389.39 |
| InChiKey | |
| InChi | |
| CAS Number | 892128-60-8 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
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| Mechanism | |
| Cell study | |
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| Clinical study |
Not available
Chemical Structure
