Linifanib is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFR with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively.
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Chemical Information
Name Linifanib
Iupac Chemical Name 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
Synonyms ABT-869; AL-39324; ABT 869; ABT869; AL 39324; AL39324
Molecular Formula C21H18FN5O
Molecular Weight 375.399
Smile CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
InChiKey MPVGZUGXCQEXTM-UHFFFAOYSA-N
InChi InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
CAS Number 796967-16-3
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation Solid powder
Purity 98%
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study