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Lunresertib

Catalog No: 24080
CAS Number: 2719793-90-3
Purity: 98% Min.

Lunresertib, alsop known as RP-6306, is a potent and selective PKMYT1 inhibitor (IC50 = 3.1 nM).

For research use only. We do not sell to patients.

Chemical Information

NameLunresertib
Iupac Chemical Name2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
SynonymsRP-6306; (Rac)-RP-6306; RP 6306; RP6306; lunresertib
Molecular FormulaC18H20N4O2
Molecular Weight324.38
SmileO=C(C1=C(N)N(C2=C(C)C(O)=CC=C2C)C3=C1C=C(C)C(C)=N3)N
InChiKeyARBRHWRTXPWZGN-UHFFFAOYSA-N
InChiInChI=1S/C18H20N4O2/c1-8-5-6-13(23)10(3)15(8)22-16(19)14(17(20)24)12-7-9(2)11(4)21-18(12)22/h5-7,23H,19H2,1-4H3,(H2,20,24)
CAS Number2719793-90-3
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
FormulationOff-white solid
Purity98% Min.
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Szychowski J, Papp R, Dietrich E, Liu B, Vallée F, Leclaire ME, Fourtounis J,
Martino G, Perryman AL, Pau V, Yin SY, Mader P, Roulston A, Truchon JF, Marshall
CG, Diallo M, Duffy NM, Stocco R, Godbout C, Bonneau-Fortin A, Kryczka R,
Bhaskaran V, Mao D, Orlicky S, Beaulieu P, Turcotte P, Kurinov I, Sicheri F,
Mamane Y, Gallant M, Black WC. Discovery of an Orally Bioavailable and Selective
PKMYT1 Inhibitor, RP-6306. J Med Chem. 2022 Aug 11;65(15):10251-10284. doi:
10.1021/acs.jmedchem.2c00552. Epub 2022 Jul 26. PMID: 35880755; PMCID:
PMC9837800.

2: Gallo D, Young JTF, Fourtounis J, Martino G, Álvarez-Quilón A, Bernier C,
Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah
PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S,
Fugère-Desjardins C, Goullet de Rugy T, Leclaire ME, Liu B, Bhaskaran V, Mamane
Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkáč J, Yin SY, Morris SJ, Zinda
M, Marshall CG, Durocher D. CCNE1 amplification is synthetic lethal with PKMYT1
kinase inhibition. Nature. 2022 Apr;604(7907):749-756. doi:
10.1038/s41586-022-04638-9. Epub 2022 Apr 20. PMID: 35444283; PMCID: PMC9046089.

3: Qi X, Li G, Liu J, Mou L, Zhang Y, Guo S, Chen X, Li W. Structural and
energetic insights into the selective inhibition of PKMYT1 against WEE1. J
Biomol Struct Dyn. 2023 Jun 22:1-9. doi: 10.1080/07391102.2023.2225106. Epub
ahead of print. PMID: 37345529.

Chemical Structure

24080 - Lunresertib | CAS 2719793-90-3

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