MDK-7553
MDK-7553, also known as CD38 inhibitor 78c and Compound-78c, is a potent CD38 inhibitor. MDK-7553 has CAS#1700637-55-3, which was reported in J Med Chem. 2015 Apr 23;58(8):3548-71. For the convenience of scientific communication, we name it as MDK-7553. The last four digits of CAS# were used for its name.
For research use only. We do not sell to patients.
Chemical Information
| Name | MDK-7553 |
|---|---|
| Iupac Chemical Name | 4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one |
| Synonyms | CD38 inhibitor 78c; Compound-78c; CD38i_78c; 78c; Cluster of Differentiation 38 Inhibitor; MDK-7553; MDK 7553; MDK7553; CD38-IN-78c; CD38 IN-78c; CD38IN-78c: CD38 inhibitor 78c; |
| Molecular Formula | C22H27N3O3S |
| Molecular Weight | 413.53 |
| Smile | O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1 |
| InChiKey | VJQALSOBHVEJQM-QAQDUYKDSA-N |
| InChi | InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17- |
| CAS Number | 1700637-55-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune
MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG,
Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.
Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors
of NAD-Hydrolyzing Enzyme CD38. J Med Chem. 2015 Sep 10;58(17):7021-56. doi:
10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24. PubMed PMID: 26267483.
2: Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud
M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL,
Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 Inhibitor
Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline.
Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.
PubMed PMID: 29719225; PubMed Central PMCID: PMC5935140.
Chemical Structure
