MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM.
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Name | MELK-8a |
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Iupac Chemical Name | Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]- |
Synonyms | MELK-8a;Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]- |
Molecular Formula | C25H32N6O |
Molecular Weight | 432.56 |
Smile | CN1CCN(C2=CC=C(N3N=CC(C4=C(OCC5CCNCC5)C=NC=C4)=C3)C=C2)CC1 |
InChiKey | BLFBSGVUERKSST-UHFFFAOYSA-N |
InChi | InChI=1S/C25H32N6O/c1-29-12-14-30(15-13-29)22-2-4-23(5-3-22)31-18-21(16-28-31)24-8-11-27-17-25(24)32-19-20-6-9-26-10-7-20/h2-5,8,11,16-18,20,26H,6-7,9-10,12-15,19H2,1H3 |
CAS Number | 1922153-17-0 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | Solid powder |
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Purity | 98% Min. |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |