MGD-28
MGD-28 is a potent molecular glue degrader that demonstrates significant in vitro efficacy against various hematological cancer cell lines. It induces degradation of Ikaros family zinc finger proteins 1, 2, and 3 (IKZF1/2/3) and casein kinase 1 alpha (CK1α) with nanomolar potency via a Cullin-cereblon (CRBN) dependent pathway. Compared to lenalidomide and pomalidomide, MGD-28 achieves deeper, faster, and more potent degradation of these neosubstrates. Additionally, MGD-28 exhibits broad antiproliferative activity in multiple solid malignancies and shows preferential cytotoxicity toward multiple myeloma patient-derived cells at various disease stages.
For research use only. We do not sell to patients.
Chemical Information
| Name | MGD-28 |
|---|---|
| Iupac Chemical Name | 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-3-methyl-1-oxo-1,2,3,4-tetrahydrophthalazin-5-yl)amino)methyl)benzyl)piperazin-1-yl)-2-fluorobenzonitrile |
| Synonyms | MGD-28; MGD 28; MGD28; |
| Molecular Formula | C33H34FN7O3 |
| Molecular Weight | 595.67 |
| Smile | CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6 |
| InChiKey | JICHBFQDRLGJTM-UHFFFAOYSA-N |
| InChi | InChI=1S/C33H34FN7O3/c1-38-21-27-26(33(44)41(38)30-11-12-31(42)37-32(30)43)3-2-4-29(27)36-19-22-5-7-23(8-6-22)20-39-13-15-40(16-14-39)25-10-9-24(18-35)28(34)17-25/h2-10,17,30,36H,11-16,19-21H2,1H3,(H,37,42,43) |
| CAS Number | 2991818-13-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Li P, Hu X, Fan Z, Sun S, Ran Q, Wei T, Wei P, Jiang Q, Yan J, Yang N, Jia C, Yang T, Mao Y, Cai X, Xu T, Zhao Z, Qian X, Qin W, Zhuang X, Fan F, Xiao J, Zheng Z, Li S. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation. J Hematol Oncol. 2024 Sep 2;17(1):77. doi: 10.1186/s13045-024-01592-z. PMID: 39218923; PMCID: PMC11367868.
Chemical Structure
