MI-2 (MALT1 inhibitor)
Catalog No: 16123047
CAS Number: 1047953-91-2
Purity: 98%
MI-2 is a MALT1 inhibitor (IC50 = 5.84 M). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-B activity induced by MALT1. Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), a paracaspase and essential regulator for nuclear factor kB (NF-B) activation, plays an important role in innate and adaptive immunity. Suppression of MALT1 protease activity with small molecule inhibitors showed promising efficacies in subtypes of B cell lymphoma and improvement in experimental autoimmune encephalomyelitis model.
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Chemical Information
| Name | MI-2 (MALT1 inhibitor) |
|---|---|
| Iupac Chemical Name | MI-2 (MALT1 inhibitor) |
| Synonyms | MI 2; MI2 |
| Molecular Formula | C19H17Cl3N4O3 |
| Molecular Weight | 455.72 |
| InChiKey | |
| InChi | |
| CAS Number | 1047953-91-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
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| Mechanism | |
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| Clinical study |
Not available
Chemical Structure
