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MIF098

Catalog No: 24150
CAS Number: 1208448-95-6
Purity: 98% Min.

MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.


For research use only. We do not sell to patients.

Chemical Information

NameMIF098
Iupac Chemical Name3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one
SynonymsMIF098; MIF-098; MIF 098
Molecular FormulaC15H13NO3
Molecular Weight255.27
SmileO=C1OC2=CC=C(C)C=C2N1CC3=CC=CC(O)=C3
InChiKeyJJXKGUBHEQGADG-UHFFFAOYSA-N
InChiInChI=1S/C15H13NO3/c1-10-5-6-14-13(7-10)16(15(18)19-14)9-11-3-2-4-12(17)8-11/h2-8,17H,9H2,1H3
CAS Number1208448-95-6
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid
Purity98% Min.
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Huang H, Chen D, Pu J, Yuan A, Fu Q, Li J, Leng L, Bucala R, Ye S, Lu L. The
small molecule macrophage migration inhibitory factor antagonist MIF098,
inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol.
2019 Nov;76:105874. doi: 10.1016/j.intimp.2019.105874. Epub 2019 Sep 6. PMID:
31499270.

2: Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors
MA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Markewych A, Bitto A, Sindler AL,
Cortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM,
Bogue M, Miller RA. 17-a-estradiol late in life extends lifespan in aging UM-
HET3 male mice; nicotinamide riboside and three other drugs do not affect
lifespan in either sex. Aging Cell. 2021 May;20(5):e13328. doi:
10.1111/acel.13328. Epub 2021 Mar 31. Erratum in: Aging Cell. 2022
Nov;21(11):e13672. doi: 10.1111/acel.13672. PMID: 33788371; PMCID: PMC8135004.

3: Shin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy
S, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Regulates U1 Small
Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome.
Arthritis Rheumatol. 2019 Jan;71(1):109-120. doi: 10.1002/art.40672. Epub 2018
Dec 4. PMID: 30009530; PMCID: PMC6310104.

4: Poulsen KL, McMullen MR, Huang E, Kibler CD, Sheehan MM, Leng L, Bucala R,
Nagy LE. Novel Role of Macrophage Migration Inhibitory Factor in Upstream
Control of the Unfolded Protein Response After Ethanol Feeding in Mice. Alcohol
Clin Exp Res. 2019 Jul;43(7):1439-1451. doi: 10.1111/acer.14065. Epub 2019 May
14. PMID: 31009094; PMCID: PMC6602811.

5: Ma F, Hunt DE, Leng L, Bucala R, Meyer-Siegler KL, Vera PL. Protease
activated-receptor 4 activation as a model of persistent bladder pain: Essential
role of macrophage migration inhibitory factor and high mobility group box 1.
Int J Urol. 2018 Oct;25(10):887-893. doi: 10.1111/iju.13778. Epub 2018 Aug 15.
PMID: 30112848; PMCID: PMC6436093.

Chemical Structure

24150 - MIF098 | CAS 1208448-95-6

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