MK-8617 is a potent, selective, orally bioavailabl Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1−3 (HIF PHD1−3) for the Treatment of Anemia.
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Chemical Information
Name MK-8617
Synonyms MK-8617; MK 8617; MK8617.
Molecular Formula C24H21N5O4
Molecular Weight 443.463
Smile O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
InChiKey WXLPERVDMILVIF-UHFFFAOYSA-N
InChi InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31)
CAS Number 1187990-87-9
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Ordering Information
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Formulation off-white solid
Purity >98%
Storage 3 years -20ºCpowder
Solubility Soluble in DMSO, not in water
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study