ML-277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks.
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Chemical Information
Name ML-277
Iupac Chemical Name 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Synonyms ML-277; ML 277; ML277; Chk2 Inhibitor II.
Molecular Formula C20H14ClN3O2
Molecular Weight 363.8
Smile ClC1=CC=C(OC2=CC=C(C=C2)C2=NC3=C(N2)C=CC(=C3)C(=O)N)C=C1
InChiKey UXGJAOIJSROTTN-UHFFFAOYSA-N
InChi InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
CAS Number 516480-79-8
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation off-white solid
Purity 98.0%
Storage -20 ℃ for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study