ML192
ML192, also known as MLS000526305 and CID1434953, is a selective ligands for GPR55. The orphan G protein coupled receptor, ML192 (CID1434953) with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2. GPR55 has gained notoriety because of its putative identification as a cannabinoid receptor subtype. The significance of this assignment should not be underestimated given the importance of cannabinoids to drug abuse and the potential utility of cannabinoid ligands in treating behavioral disorders leading to conditions such as obesity.
For research use only. We do not sell to patients.
Chemical Information
| Name | ML192 |
|---|---|
| Iupac Chemical Name | furan-2-yl(4-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl)methanone |
| Synonyms | ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. |
| Molecular Formula | C20H22N4O2S |
| Molecular Weight | 382.48 |
| Smile | CC1=NC(N2CCN(CC2)C(=O)C3=CC=CO3)=C4C(SC5=C4CCCC5)=N1 |
| InChiKey | GDPDARVUXXOYAJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H22N4O2S/c1-13-21-18(17-14-5-2-3-7-16(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)15-6-4-12-26-15/h4,6,12H,2-3,5,7-11H2,1H3 |
| CAS Number | 460331-61-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Kotsikorou E, Sharir H, Shore DM, Hurst DP, Lynch DL, Madrigal KE,
Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak LS,
Croatt MP, Abood ME, Reggio PH. Identification of the GPR55 antagonist binding
site using a novel set of high-potency GPR55 selective ligands. Biochemistry.
2013 Dec 31;52(52):9456-69. doi: 10.1021/bi4008885. Epub 2013 Dec 17. PubMed
PMID: 24274581; PubMed Central PMCID: PMC3970910.
2: Heynen-Genel S, Dahl R, Shi S, Milan L, Hariharan S, Sergienko E, Hedrick M,
Dad S, Stonich D, Su Y, Vicchiarelli M, Mangravita-Novo A, Smith LH, Chung TDY,
Sharir H, Caron MG, Barak LS, Abood ME. Screening for Selective Ligands for GPR55
- Antagonists. 2010 Oct 30 [updated 2011 May 26]. Probe Reports from the NIH
Molecular Libraries Program [Internet]. Bethesda (MD): National Center for
Biotechnology Information (US); 2010-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK66153/
PubMed PMID: 22091481.
Chemical Structure
