MTI-31
MTI-31 is a bioactive chemical.
For research use only. We do not sell to patients.
Chemical Information
| Name | MTI-31 |
|---|---|
| Iupac Chemical Name | Benzamide, N-methyl-3-(2-((3S)-3-methyl-4-morpholinyl)-4-(3-oxa-8-azabicyclo(3.2.1)oct-8-yl)pyrido(2,3-d)pyrimidin-7-yl)- |
| Synonyms | MTI-31; MTI 31; MTI31 |
| Molecular Formula | C26H30N6O3 |
| Molecular Weight | 474.55 |
| Smile | O=C(NC)C1=CC=CC(C2=NC3=NC(N4[C@@H](C)COCC4)=NC(N5C6COCC5CC6)=C3C=C2)=C1 |
| InChiKey | LVPBYQVQBZLDAU-DZIBYMRMSA-N |
| InChi | InChI=1S/C26H30N6O3/c1-16-13-34-11-10-31(16)26-29-23-21(24(30-26)32-19-6-7-20(32)15-35-14-19)8-9-22(28-23)17-4-3-5-18(12-17)25(33)27-2/h3-5,8-9,12,16,19-20H,6-7,10-11,13-15H2,1-2H3,(H,27,33)/t16-,19?,20?/m0/s1 |
| CAS Number | 1567915-38-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Zhang Q, Zhang Y, Chen Y, Qian J, Zhang X, Yu K. A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer. Clin Cancer Res. 2019 Jun 15;25(12):3630-3642. doi: 10.1158/1078-0432.CCR-18-2548. Epub 2019 Feb 22. PMID: 30796032.
2: Wang X, Meng N, Wang S, Zhang Y, Lu L, Wang R, Ruan H, Jiang K, Wang H, Ran D, Zhan C, Yu K, Burgess DJ, Lu W. Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes. J Control Release. 2019 Dec 28;316:381-392. doi: 10.1016/j.jconrel.2019.11.005. Epub 2019 Nov 12. PMID: 31730912.
3: Qian J, Chen Y, Meng T, Ma L, Meng L, Wang X, Yu T, Zask A, Shen J, Yu K. Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer. Oncotarget. 2016 Oct 11;7(41):67071-67086. doi: 10.18632/oncotarget.11490. PMID: 27563814; PMCID: PMC5341858.
Chemical Structure
